Heart failure & cardiomyopathiesMeta-analysis
Geographical Variation in Patient Characteristics and Outcomes in Heart Failure with Mildly Reduced and Preserved Ejection Fraction
- Individual patient analysis of five clinical trials
- pooled individual patient data
- multivariable regression
Authors' conclusion
There is substantial geographic variation in patient characteristics, treatment and outcomes among patients with HFpEF and HFmrEF.
Study context
- Population
- Patients with HF with preserved ejection fraction (HFpEF) or HF with mildly reduced ejection fraction (HFmrEF) enrolled in five clinical trials
- Participants
- 19,959 patients · 5 trials
- Comparison
- Geographic regions
- Outcome
- CV death or HF hospitalization
Pooled result
As reported in the abstract
CV death or HF hospitalization, HFmrEF (per 100 patient-years)
Further pooled results
| Outcome | Values |
|---|---|
| CV death or HF hospitalization, HFpEF (per 100 patient-years) | NA 11.47 /100py · AP 7.80 /100py · CEER 5.47 /100py · LA 5.92 /100py · WE 7.80 /100py |
- CV death or heart failure (HF) hospitalization, HFpEF (per 100 patient-years): HFpEF n = 15 353 (76.9%)
Patient characteristics by region
- Western Europe (WE) oldest, Central/Eastern Europe and Russia (CEER) youngest; Latin America (LA) most females; North America (NA) most black patients
- Obesity and DM most prevalent in NA; hypertension and CHD most common in CEER
- Self-reported health status worst in NA, best in Asia-Pacific (AP)
Original publication
Geographical Variation in Patient Characteristics and Outcomes in Heart Failure with Mildly Reduced and Preserved Ejection Fraction. Eur J Heart Fail. Published 23 June 2024. doi:10.1002/ejhf.3352
Summarised from the published abstract; every number is checked against it