Gestational Blood Pressure Trajectories and 5-Year Postpartum Hypertension Risk in the MADRES Study
Authors' conclusion
Pregnant individuals with consistently elevated SBP yet within the subclinical range face longer-term risk of hypertension but may not be captured by standard prenatal clinical guidelines.
Study context
- Population
- Pregnant individuals in the MADRES (Maternal and Developmental Risks from Environmental and Social Stressors) cohortpregnant individuals followed from early pregnancy to 5 years postpartum
- Participants
- 854 individuals
- Exposure
- Gestational systolic blood pressure (SBP) trajectory groups and the risk of hypertension at 2 to 5 years postpartum
- Consistently lown = 685
- Consistently elevatedn = 106
- High-drop-highn = 63
- Outcome
- Gestational SBP trajectory groups
- Follow-up
- Over pregnancy
Methodological detailsfollowed from early pregnancy to 5 years postpartum, latent class growth modeling, Cox modeling
- Followed from early pregnancy to 5 years postpartum
- Latent class growth modeling
- Cox modeling
Main finding
As reported in the abstract
- 3 distinct gestational SBP trajectory groups
- 3
Observational data: associations, not effects.
Further findings
| Outcome | Fold higher risk (95% CI) |
|---|---|
| Risk of hypertension · 5 years postpartumConsistently elevated vs consistently low · higher in consistently elevated group · after adjusting for covariates | 4.91 (2.01–12.0) |
| Risk of hypertension · 5 years postpartumHigh-drop-high vs consistently low · higher in high-drop-high group · after adjusting for covariates | 5.44 (1.89–15.7) |
Original publication
Gestational Blood Pressure Trajectories and 5-Year Postpartum Hypertension Risk in the MADRES Study. JACC Adv. Published 17 March 2025. doi:10.
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