Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data
Authors' conclusion
This study demonstrated a suggestive causal relationship between genetic predisposition to gestational diabetes mellitus and the risk of coronary artery disease, which was mainly mediated by Type 2 diabetes and hypertension.
Study context
- Population
- Ever-pregnant women; GDM GWAS summary statistics from FinnGen, CVD from UK Biobank individual-level genetic data
- Comparison
- Genetic predisposition to gestational diabetes mellitus and risk of CVD
- Outcome
- CAD and MI risk per unit increase in log-odds of genetic predisposition to GDM (ever-pregnant women)
Methodological detailssex-specific, two-sample Mendelian randomization, linkage disequilibrium score regression, two-step Mendelian randomization mediation analysis
- Sex-specific
- Two-sample Mendelian randomization
- Linkage disequilibrium score regression
- Two-step Mendelian randomization mediation analysis
Main finding
As reported in the abstract
Genetic predisposition to gestational diabetes mellitusOdds ratio (95% CI)
CAD, per unit increase in log-odds, ever-pregnant women
1.09(1.01–1.17)
MI, per unit increase in log-odds, ever-pregnant women
1.12(.96-1.31)
Per unit increase in log-odds, as printed
Further findings
Genetic correlation (LD score regression)
- Significant genetic correlation of GDM with CAD and MI after Benjamini-Hochberg correction in ever-pregnant women
Mediation of GDM–CAD causality
- T2DM and hypertension identified as mediators
Sensitivity analysis: instruments with GDM-predominant effects and CAD
- OR direction consistent with primary results in ever-pregnant women, not statistically significant
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data. Eur Heart J. Published 25 October 2024. doi:10.
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