Heart failure & cardiomyopathiesResearch article
Global Burden and Disparities in Pediatric Heart Failure
- Global Burden of Disease (GBD) 2021 analysis
- stratified by age, gender, region, country and sociodemographic index
Authors' conclusion
This study underscores the growing burden of PHF and the urgent need for targeted interventions to alleviate its impact.
Study context
- Population
- Children and young people aged 0–20 years with heart failure (HF) (pediatric heart failure (PHF)), worldwide, 1990–2021
- Outcome
- Prevalence, years lived with disability and estimated annual percentage changes of PHF
Main finding
As reported in the abstract
Global prevalence of PHF · 2021
Global prevalence of PHF, cases
6.01 million
Global prevalence rate of PHF
228 per 100,000
Further findings
Change in PHF prevalence rate · 1990 to 2021
- Increase in prevalence rate
- 8.78%
- Significant differences by gender, age, country and region
Sociodemographic index and PHF prevalence
- Positive correlation
- P < 0.001
Leading causes of PHF
- Congenital heart anomalies, other cardiomyopathies, rheumatic heart disease and CKD, with varying trends over time
Years lived with disability · forecast to 2050
- Increase mirrored prevalence; consistent upward trend in PHF burden forecast by 2050
Original publication
Global Burden and Disparities in Pediatric Heart Failure. JACC Heart Fail. Published 24 June 2025. doi:10.1016/j.jchf.2025.03.032
Summarised from the published abstract; every number is checked against it