Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019
Authors' conclusion
The global incidence rate of early-onset IHD decreased from 1990 to 2019. The incidence rate was highest in low-middle SDI countries, and the burden of DALY was highest in low-middle SDI countries. The DALY and death rate were higher in men. High low-density lipoprotein cholesterol and high systolic blood pressure were the primary attributors.
Study context
- Population
- Early-onset ischemic heart disease (men <55 years, women <65 years), 204 countries and territories, 1990–2019204 countries and territories
- Outcome
- Incidence, prevalence and DALY of early-onset ischemic heart disease (IHD)
- Follow-up
- 1990 to 2019
Methodological details204 countries and territories, 1990–2019
- 204 countries and territories
- 1990–2019
Main finding
As reported in the abstract
Global burden of early-onset IHD · 2019
Individuals affected globally
5.34 million
95% UI 3.96–6.96
Disability-adjusted life years (DALY)
58.48 million
95% UI 52.65–64.69
Deaths
1.44 million
95% UI 1.29–1.59
Further findings
| Outcome | Female | Male |
|---|---|---|
| Incidence cases by sex · 2019 | 2.77 million (95% UI 2.04–3.64) | 2.57 million (95% UI 1.92–3.32) |
Burden by sociodemographic index (SDI) · 2019
- Middle SDI: highest incidence cases
- 1.79 million (95% UI 1.32-2.34)
- Low-middle SDI: highest age-standardized incidence rate
- 179.34 per 100,000 (95% UI 134.38-231.94)
- Low-middle SDI: highest age-standardized death rate
- 57.13 per 100,000 (95% UI 48.45-66.53)
- Low-middle SDI: highest age-standardized DALY rate
- 2,309.67 per 100,000 (95% UI 1962.31-2,693.93)
Attributable risk factors
- Top 2: high LDL-C and high SBP
Original publication
Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019. JACC Adv. Published 20 December 2024. doi:10.
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