Valvular & structural heart diseaseResearch article
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017
- Global Burden of Disease Study (descriptive modelling study)
- 195 countries and territories
- 1990–2017
Authors' conclusion
These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults.
Study context
- Population
- 195 countries and territories, 1990–2017
- Comparison
- Calcific aortic valve disease (CAVD) vs Degenerative mitral valve disease
- Outcome
- Mortality, prevalence and DALYs of nonrheumatic valvular diseases
- Follow-up
- 2017
Main finding
As reported in the abstract
| Group | Deaths | Prevalent cases |
|---|---|---|
| CAVD | 102 700 (95% UI, 82 700-107 900) | 12.6 million (95% UI, 11.4 million-13.8 million) |
| Degenerative mitral valve disease | 35 700 (95% UI, 30 500-42 500) | 18.1 million (95% UI, 17.6 million-18.6 million) |
- Disability-adjusted life-years (DALYs) from nonrheumatic valvular diseases globally
- 2.5 million (95% UI, 2.3 million-2.8 million)
- Share of total lost health from all diseases
- 0.10% (95% UI, 0.09%-0.11%)
Further findings
| Outcome | CAVD | Degenerative mitral valve disease |
|---|---|---|
| Increase in DALYs · 1990 to 2017 | 101% (95% UI 79%–117%) | 35% (95% UI 23%–47%) |
Geographic variation
- Significant geographic variation in prevalence, mortality and burden; highest age-standardized CAVD DALY rates in high-income countries
Original publication
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017. Circulation. Published 29 March 2020. doi:10.1161/circulationaha.119.043391
Summarised from the published abstract; every number is checked against it