Valvular & structural heart disease
GLP-1 receptor agonist treatment and cardiovascular outcomes following aortic valve replacement: a nationwide observational study
Main finding · Composite of all-cause mortality, heart failure hospitalization, or aortic valve reoperationResult — go to the resultHazard ratio 0.69 95% CI 0.50–0.96- Nationwide population-based cohort study
- propensity score-matched
- consecutive patients
- Western Denmark
+3 more
- propensity score-matched
- consecutive patients
- Western Denmark
Authors' conclusion
Treatment with GLP-1 receptor agonists was associated with lower risk of cardiovascular outcomes including mortality following AVR among patients with severe AS.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing TAVI or SAVR in Western Denmark between January, 2016 and April, 2022propensity score-matched patients included in the final analyses, among 5259 eligible patients undergoing aortic valve replacement (AVR)
- Participants
- 292 patients
- Exposure
- GLP-1 receptor agonist treatment compared with controls
- Outcome
- Composite of:
- All-cause mortality
- Heart failure hospitalization
- Aortic valve reoperation
- Follow-up
- Mean 4.8±2.4 years
Main finding
As reported in the abstract
Composite of:
- All-cause mortality
- Heart failure hospitalization
- Aortic valve reoperation
Hazard ratio
0.69
95% CI 0.50–0.96
P = 0.029
GLP-1 receptor agonist treatment vs controls
HR 0.69 (95% CI 0.50–0.96); P = 0.029
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality | 0.66 (0.46–0.95) | P = 0.025 | |
| Heart failure hospitalization · competing risk analysis accounting for death | 0.67 (0.48–0.93) | P = 0.018 | |
| Aortic valve reoperation · competing risk analysis accounting for death | 0.69 (0.49–0.98) | P = 0.037 | |
| 0.512Hazard ratio (log scale) |
Original publication
GLP-1 receptor agonist treatment and cardiovascular outcomes following aortic valve replacement: a nationwide observational study. Eur J Heart Fail. Published 16 October 2026. doi:10.
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Summarised from the published abstract; every number is checked against it