Coronary disease & ACSCohort study
Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction
- Prospective cohort study
Authors' conclusion
In patients hospitalized for myocardial infarction, GLP-1 levels are associated with cardiovascular events.
Study context
- Population
- Patients presenting with MI (STEMI and NSTEMI)321 STEMI, 597 NSTEMI
- Participants
- 918 patients
- Exposure
- Admission GLP-1 levels and CV outcome
- Outcome
- First occurrence of CV death, non-fatal MI or non-fatal stroke
Main finding
As reported in the abstract
Primary composite outcome per logarithmized GLP-1
logarithmized GLP-1Hazard ratio (95% CI)P value
univariable
6.29(2.67–14.81)
P < 0.0001adjusted incl. age, sex, diabetes, GFR, hs-CRP, hs-Troponin T, NT-proBNP
10.98(2.63–45.90)
P = 0.0010Per logarithmized GLP-1, as printed
Observational data: associations, not effects.
Further findings
Early events (up to 30 days), time-dependent ROC · up to 30 days after admission
- GLP-1 superior to hs-Troponin T, glomerular filtration rate (GFR) CKD-EPI, hs-CRP and NT-proBNP
Global Registry of Acute Coronary Events (GRACE) risk estimate plus GLP-1 (NSTEMI)
- Addition of GLP-1 increased AUC over time in NSTEMI
Original publication
Glucagon-like peptide 1 levels predict cardiovascular risk in patients with acute myocardial infarction. Eur Heart J. Published 16 October 2019. doi:10.1093/eurheartj/ehz728
Summarised from the published abstract; every number is checked against it