Coronary disease & ACSCohort study
Glycemic Control and Coronary Stent Failure in Patients With Type 2 Diabetes Mellitus
- Observational cohort study
- nationwide (Sweden)
- complete cases model
- sensitivity analyses for missing data and death as competing risk
Authors' conclusion
We found a significant association between poor glycemic control and a higher risk of stent failure driven by in-stent restenosis.
Study context
- Population
- Patients in Sweden with T2DM receiving second-generation drug-eluting stents, 2010–202024,411 complete cases
- Participants
- 52,457 patients
- Exposure
- HbA1c categories vs HbA1c 6.1%–7.0%
- Outcome
- Stent failure (in-stent restenosis and stent thrombosis)
- Follow-up
- Median 6.4 years
Main finding
As reported in the abstract
Stent failure by updated mean HbA1c
Each group vs HbA1c 6.1%–7.0%Hazard ratio (95% CI)
HbA1c ≤5.5%
1.10(0.80–1.52)
HbA1c 5.6%–6.0%
1.02(0.85–1.23)
HbA1c 7.1%–8.0%
1.25(1.11–1.41)
HbA1c 8.1%–9.0%
1.30(1.13–1.51)
HbA1c 9.1%–10.0%
1.46(1.21–1.76)
HbA1c ≥10.1%
1.33(1.06–1.66)
Observational data: associations, not effects.
Further findings
Sensitivity analyses (missing data; death as competing risk)
- Sensitivity analyses did not change the main result
Original publication
Glycemic Control and Coronary Stent Failure in Patients With Type 2 Diabetes Mellitus. J Am Coll Cardiol. Published 14 May 2024. doi:10.1016/j.jacc.2024.04.012
Summarised from the published abstract; every number is checked against it