Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents: A Cohort Study
Authors' conclusion
We identified novel GPCs strongly associated with multiple CVD risk factors in adolescents.
Study context
- Population
- Adolescents (12–18 years, 48% male), Saguenay Youth Study69 serum glycerophosphocholine (GPCs) identified
- Participants
- 990 adolescents
- Outcome
- Association of serum GPCs with CVD risk factors (excess visceral fat, elevated BP, insulin resistance, atherogenic dyslipidemia)
Methodological detailspopulation-based, targeted serum lipidomics, visceral fat (VF) measured with MRI, Liquid chromatography-electrospray ionization-mass spectrometry
- Population-based
- Targeted serum lipidomics
- VF measured with MRI
- Liquid chromatography-electrospray ionization-mass spectrometry
Main finding
As reported in the abstract
Associations of novel GPCs with CVD risk factors
- PC16:0/2:0 negatively associated with VF
- P=1.4×10-19
- PC16:0/2:0 negatively associated with BP
- P=7.7×10-5
- PC16:0/2:0 negatively associated with fasting triacylglycerols
- P=9.0×10-5
- PC14:1/0:0 positively associated with VF
- P=3.0×10-7
- PC14:1/0:0 positively associated with fasting insulin
- P=5.4×10-32
- PC14:1/0:0 positively associated with triacylglycerols
- P=1.4×10-29
Observational data: associations, not effects.
Further findings
Mediation of VF–cardiovascular disease (CVD) risk factor relations by GPCs (Sobel test)
- Both GPCs mediated their respective relations between VF (exposure) and CVD risk factors (outcomes)
- P < 1.3×10-3
PC18:2/0:0 (predicts incident CHD in older adults)
- Associated with several CVD risk factors; less strong than newly identified GPCs
Original publication
Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents: A Cohort Study. Circulation. Published 18 October 2016. doi:10.
Summarised from the published abstract; every number is checked against it