Acute cardiac care & resuscitation
Good outcome prediction after out-of-hospital cardiac arrest: A prospective multicenter observational study in Korea (the KORHN-PRO registry)
Authors' conclusion
Clinical examination, biomarker, electrophysiology, and brain imaging predicted good outcomes at 6 months after CA. When the two predictors were combined, the specificity further improved.
Study context
- Population
- Adult (≥18 years) Out-of-hospital Cardiac Arrest (OHCA) patients, Korean Hypothermia Network Prospective Registry 1.0412 with good outcome
- Participants
- 1,327 participants
- Comparison
- Clinical examination, biomarkers, electrophysiology and brain imaging, individually or combined, for predicting good neurological outcome
- Outcome
- Good neurological outcome
- Follow-up
- 6 months
Methodological detailsretrospective analysis of prospective registry, multicentre
- Retrospective analysis of prospective registry
- Multicentre
Performance
As reported in the abstract
Prediction of good neurological outcome
| Test or model | Sensitivity (highest) | Sensitivity | Specificity (highest) | Specificity |
|---|---|---|---|---|
| GCS-M >3 | Not reported in the abstract | Not reported in the abstract | 96.7% (95% CI 95.3-97.8) | Not reported in the abstract |
| Normal brain diffusion-weighted imaging (DWI) | 96.3% (95% CI 92.9-98.4) | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract |
| Two predictors combined | Not reported in the abstract | 2.7-81.1% | Not reported in the abstract | 81.3-100% |
| European Resuscitation Council (ERC)/European Society of Intensive Care Medicine (ESICM) algorithm variation | Not reported in the abstract | 83.5% | Not reported in the abstract | 83.2% |
Sensitivity (highest)
GCS-M >3Not reported in the abstract
Normal brain diffusion-weighted imaging (DWI)96.3% (95% CI 92.9-98.4)
Two predictors combinedNot reported in the abstract
European Resuscitation Council (ERC)/European Society of Intensive Care Medicine (ESICM) algorithm variationNot reported in the abstract
Sensitivity
GCS-M >3Not reported in the abstract
Normal brain diffusion-weighted imaging (DWI)Not reported in the abstract
Two predictors combined2.7-81.1%
European Resuscitation Council (ERC)/European Society of Intensive Care Medicine (ESICM) algorithm variation83.5%
Specificity (highest)
GCS-M >396.7% (95% CI 95.3-97.8)
Normal brain diffusion-weighted imaging (DWI)Not reported in the abstract
Two predictors combinedNot reported in the abstract
European Resuscitation Council (ERC)/European Society of Intensive Care Medicine (ESICM) algorithm variationNot reported in the abstract
Specificity
GCS-M >3Not reported in the abstract
Normal brain diffusion-weighted imaging (DWI)Not reported in the abstract
Two predictors combined81.3-100%
European Resuscitation Council (ERC)/European Society of Intensive Care Medicine (ESICM) algorithm variation83.2%
Original publication
Good outcome prediction after out-of-hospital cardiac arrest: A prospective multicenter observational study in Korea (the KORHN-PRO registry). Resuscitation. Published 4 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it