Congenital heart diseaseCohort study
Growth of the Neo-Aortic Root and Prognosis of Transposition of the Great Arteries
- Retrospective cohort study
- single-centre
Study context
- Population
- Patients who underwent the arterial switch operation (ASO) for d-TGA, July 1, 1981 to September 30, 2022
- Participants
- 1,359 patients
- Exposure
- Neo-aortic root growth by intrinsic morphology after ASO
- d-TGA-IVSn = 593reference
- d-TGA-VSDn = 666
- DORV-TGAn = 100
- Outcome
- Growth of the neo-aortic root (echocardiographic diameters and z scores at annulus, sinus of Valsalva and sinotubular junction)
Main finding
As reported in the abstract
Neo-aortic root dilatation, DORV-TGA vs d-TGA-IVS · 30 years
- DORV-TGA vs d-TGA-IVS: P < 0.001
- DORV-TGA vs d-TGA-IVS: P = 0.039
- DORV-TGA vs d-TGA-IVS: P = 0.041
- median follow-up 8.6 years (range: 0.1-39.3 years)
- median 5 echocardiograms (Q1-Q3: 3-10) per patient
Observational data: associations, not effects.
Further findings
Composite of moderate-severe aortic regurgitation (AR) and neo-aortic valve or root intervention at late follow-up (multivariable)
- Associated with intrinsic anatomy, older age at ASO, at least mild AR at baseline and high-risk root dilatation
- all P < 0.05
- multivariable Cox proportional hazards models
Original publication
Growth of the Neo-Aortic Root and Prognosis of Transposition of the Great Arteries. J Am Coll Cardiol. Published 6 November 2023. doi:10.1016/j.jacc.2023.10.023
Summarised from the published abstract; every number is checked against it