Heart failure & cardiomyopathies
GRSF1 Protects Against Heart Failure by Maintaining Branched-chain Amino Acid (BCAA) Homeostasis
Authors' conclusion
Our study identified GRSF1 as a cell-intrinsic metabolic checkpoint that maintains cardiac BCAA homeostasis by regulating BCKDHB mRNA turnover.
Study context
- Population
- Heart tissue of patients with dilated cardiomyopathy; mice with cardiomyocyte-specific GRSF1 deletion or overexpression
Methodological detailscardiomyocyte-specific knockout and overexpression mice, human DCM heart tissue
- Cardiomyocyte-specific knockout and overexpression mice
- Human DCM heart tissue
Main finding
As reported in the abstract
- GRSF1 expression significantly decreased in hearts of patients with HF and failing murine hearts
- Cardiomyocyte-specific GRSF1 deletion caused cardiac dysfunction, spontaneous progression to dilated cardiomyopathy and HF, with increased hypertrophy and fibrosis
- GRSF1 overexpression attenuated cardiac remodelling and HF induced by transverse aortic constriction
- GRSF1 maintained BCAA homeostasis and mitochondrial function by binding G-tracts in BCKDHB mRNA coding region via a quasi-RNA recognition motif, stabilising BCKDHB mRNA and increasing its protein expression
- Functional recovery with GRSF1 overexpression partially blocked by cardiac-specific BCKDHB deletion
Original publication
GRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis. Circulation. Published 5 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →