Coronary disease & ACSSecondary analysis
Guiding Preventive Care Strategies for Patients With Atherosclerotic Plaque on Coronary Computed Tomographic Angiography (CTA)
- Prospective observational pre-post interventional registry substudy
- delayed release of AI-CPA findings
Authors' conclusion
The DECIDE registry supports that AI-CPA was associated with preventive management changes, especially intensification of care for patients with more extensive plaque.
Study context
- Population
- Symptomatic patients with atherosclerotic plaque on coronary CTA
- Participants
- 972 patients
- Comparison
- Management guided by AI-CPA vs by coronary CTA stenosis measures alone
- Primary endpoint
- Change in management post AI-CPA: modification of preventive/anti-ischemic therapies, new laboratory testing, specialist referral, or referral to stress testing/invasive coronary angiography
Primary result
As reported in the abstract
Change in management after AI-CPA
Management changes after AI-CPA
51.3% (95% CI 48.2%-54.5%)
Management changes in highest plaque stage (more frequent with more extensive plaque, P < 0.001)
up to 67.8%
Further findings
Median, mg/dL
| Outcome | Management changes | No management changes | P value |
|---|---|---|---|
| Change in LDL-C | −11 (IQR −42.5–4) | 1 (IQR −18–14) | P = 0.002 |
Intensified medical therapy
- Most common management change
- 35.6%
Original publication
Guiding Preventive Care Strategies for Patients With Atherosclerotic Plaque on Coronary CTA. JACC Cardiovasc Imaging. Published 12 March 2026. doi:10.1016/j.jcmg.2026.01.014
Summarised from the published abstract; every number is checked against it