Heart failure & cardiomyopathiesCohort study
Haemodynamic gain index and heart failure incidence- Prognostic and preventive value
- Prospective cohort study
Authors' conclusion
HGI was found to be a strong predictor of HF incidence in men, supporting its prognostic value. Higher HGI was independently associated with lower risk of HF incidence, while low HGI could serve as a prognostic risk factor for HF.
Study context
- Population
- Men free from heart failure (HF) at baseline undergoing treadmill exercise testing, aged 59 ± 11.5 years297 HF cases
- Participants
- 5,539 men
- Exposure
- Haemodynamic gain index (HGI) quartiles
- Outcome
- Incident HF
- Follow-up
- 14.3 ± 6 years
Main finding
HF incidence
Hazard ratio
0.56
95% CI 0.45–0.69
P < 0.001
HGI
hazard ratio 0.56 (95% CI 0.45–0.69); P < 0.001
Per one unit higher HGI, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
HF incidence and HGI in the cohort
- Average annual HF incidence rate
- 3.7 events per 1000 person-years
- Average HGI
- 1.6 ± 0.7 bpm/mmHg
Original publication
Haemodynamic gain index and heart failure incidence- Prognostic and preventive value. Eur J Prev Cardiol. Published 31 July 2023. doi:10.1093/eurjpc/zwad236
Summarised from the published abstract; every number is checked against it