Heart failure & cardiomyopathiesCohort study
Haemodynamic response to exercise in patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction
- observational study
Authors' conclusion
Patients with HCM without LVOT obstruction exhibited significant haemodynamic impairments during exercise. Abnormally elevated LV filling pressures were present even at low workloads and were correlated with reduced exercise capacity.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) without left ventricular outflow tract (LVOT) obstruction and healthy controls undergoing right heart catheterisation during rest and supine incremental exercisesubjects who underwent right heart catheterisation · patients with HCM without LVOT obstruction 59 · healthy controls 62
- Participants
- 121 patients
- Exposure
- patients with HCM without LVOT obstruction vs healthy controls
- patients with HCM without LVOT obstructionn = 59
- healthy controlsn = 62
Main finding
As reported in the abstract
PCWP · At rest
patients with HCM without LVOT obstruction
14±6
mm Hg
healthy controls
9±2
mm Hg
P < 0.001
Observational data: associations, not effects.
Further findings
Abnormal PCWP · mild exercise and peak
mild exercise
peak
| Outcome | patients with HCM without LVOT obstruction | healthy controls | r (95% CI) | P value |
|---|---|---|---|---|
| Haemodynamics at mild exercise · mild exercise (25 W) | ||||
| PCWP | 27±7 | 16±7 | ||
| mean arterial pressure | 100±18 | 93±13 | ||
| central venous pressure | 12±6 | 9±4 | ||
| mean pulmonary artery pressure | 38±11 | 26±8 | ||
| Haemodynamics at peak exercise | ||||
| PCWP | 32±8 mm Hg | 18±8 mm Hg | ||
| cardiac index | 6.4±1.8 L/min/m² | 8.9±1.4 L/min/m² | ||
| heart rate | 114±21 bpm | 132±19 bpm | ||
| arteriovenous oxygen difference | 58±13% | 64±6% | ||
| Peak exercise capacity and peak oxygen consumption · lower in patients | ||||
| Peak exercise capacity | 119±50 W | 149±40 W | ||
| peak oxygen consumption | 21±7 mL/kg/min | 35±8 mL/kg/min | ||
| Correlation of PCWP at mild exercise with peak oxygen consumption in patients · inversely correlated | −0.61 (−0.7 to −0.4) | P < 0.001 |
- Haemodynamics at mild exercise: Pulmonary capillary wedge pressure (PCWP) p<0.001
- Haemodynamics at mild exercise: mean arterial pressure p=0.02
- Haemodynamics at mild exercise: central venous pressure p<0.001
- Haemodynamics at mild exercise: mean pulmonary artery pressure p<0.001
- Haemodynamics at peak exercise: PCWP p<0.001
- Haemodynamics at peak exercise: cardiac index p<0.001
- Haemodynamics at peak exercise: heart rate p<0.001
- Haemodynamics at peak exercise: arteriovenous oxygen difference p=0.004
- Peak exercise capacity and peak oxygen consumption: Peak exercise capacity p<0.001
- Peak exercise capacity and peak oxygen consumption: peak oxygen consumption p<0.001
Original publication
Haemodynamic response to exercise in patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction. Heart. Published 7 December 2025. doi:10.1136/heartjnl-2025-326193
Summarised from the published abstract; every number is checked against it