Arrhythmias & electrophysiology
Figure-of-8 Suture With a 3-Way Tap Versus Manual Compression After Atrial Fibrillation Ablation: The HARNESS Randomized Controlled Trial
Authors' conclusion
After AF catheter ablation, Fo8TAP was superior to MC in lowering the incidence of access site complications and was associated with health care efficiencies. However, a 2-hour bed rest strategy failed to meet noninferiority criteria versus 4 hours. (Haemostasis After Venous Access in Atrial Fibrillation Catheter Ablation [HARNESS]; NCT06470555).
Study context
- Population
- Patients undergoing atrial fibrillation (AF) ablation via unilateral femoral venous accessenrolled and randomized
- Participants
- 336 patients
- Comparison
- Superiority and noninferiority
- MC-4n = 110
- TAP-4n = 110
- TAP-2n = 116
- Primary endpoint
- any access site complication
- Follow-up
- Before hospital discharge
Primary result
As reported in the abstract
TAP-4 vs MC-4: P = 0.002 · TAP-2 vs TAP-4: P = 0.156
Secondary outcomes
Median time to hemostasis
Median time to catheter laboratory exit
Median time to mobilization
- Median time to hemostasis: P < 0.001
- Median time to catheter laboratory exit: P < 0.001
- Median time to mobilization: P < 0.001
Safety
Access site events by type
- Grade 1 bleeding
- 85/92, 92.4%
- Minor hematomas
- 7/92, 7.6%
- No major vascular complications occurred
Original publication
Figure-of-8 Suture With a 3-Way Tap Versus Manual Compression After Atrial Fibrillation Ablation: The HARNESS Randomized Controlled Trial. JACC Clin Electrophysiol. Published 19 February 2026. doi:10.
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