HDL cholesterol and clinical outcomes in diabetes mellitus
Authors' conclusion
The U-shaped association between HDL-C and clinical outcomes was amplified with worsening glucose tolerance, suggesting a potential interaction between HDL-C levels and glycaemic status on clinical outcomes.
Study context
- Population
- Adults without a history of cardiovascular disease (CVD), JMDC Claims Database, 2005–2021
- Participants
- 3,282,389 adults
- Exposure
- HDL cholesterol (HDL-C) level across fasting plasma glucose (FPG) categories
- Outcome
- Composite CVD outcome:
- MI
- Stroke
- All-cause death
- Follow-up
- Mean 1181 ± 932 days
Main finding
As reported in the abstract
Composite CVD outcome
- 35 233 composite CVD events recorded
- Association between low HDL-C and CVD risk increased with FPG level
- Relationship of high HDL-C with CV outcome prominent only in DM
Observational data: associations, not effects.
Further findings
Individual subgroups and each CV outcome
- Similar relationship observed
Original publication
HDL cholesterol and clinical outcomes in diabetes mellitus. Eur J Prev Cardiol. Published 4 February 2023. doi:10.
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