Secondary analysis
Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease
- Secondary analysis of the ISCHEMIA randomised trial
Authors' conclusion
Older patients with chronic coronary disease and moderate or severe ischemia had consistent improvement in angina frequency but less improvement in angina-related health status with invasive management compared with younger patients. Invasive management was not associated with improved clinical outcomes in older or younger patients.
Study context
- Population
- Adults with chronic coronary disease and moderate or severe ischemia
- Participants
- 4,617 adults
- Comparison
- Invasive vs conservative management, by age
- Primary endpoint
- Angina-specific health status (7-item SAQ summary score, 0-100; higher = better) and composite of CV death, MI, or hospitalization for resuscitated cardiac arrest, unstable angina or HF, by age
- Follow-up
- 1 year (SAQ)
Primary result
As reported in the abstract
1-year SAQ summary score difference (invasive minus conservative), fully adjusted, by age · 1 year
Invasive vs ConservativeDifference (95% CI)
age 55 years
4.90(3.56–6.24)
age 65 years
3.48(2.40–4.57)
age 75 years
2.13(0.75–3.51)
- No age differences in invasive vs conservative effect on composite clinical outcome
- P for interaction = 0.29
Further findings
Age distribution
Age distribution
- Baseline Seattle Angina Questionnaire (SAQ) summary scores lower in participants aged <65 years
SAQ Angina Frequency improvement by age
- Improvement less dependent on age
- P for interaction = 0.08
Original publication
Health Status and Clinical Outcomes in Older Adults With Chronic Coronary Disease. J Am Coll Cardiol. Published 2 May 2023. doi:10.1016/j.jacc.2023.02.048
Summarised from the published abstract; every number is checked against it