Valvular & structural heart diseaseSecondary analysis
Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis
- Secondary analysis of the PARTNER 3 randomised trial
- 1:1 randomisation
- mixed effects models for repeated measures adjusted for baseline
Authors' conclusion
Patients with severe aortic stenosis at low surgical risk had substantial improvement in patient-reported health status with either TAVR or SAVR that was sustained through 7 years. Patients had earlier recovery with TAVR, but health status outcomes after 2 years were similar between treatment groups.
Study context
- Population
- Patients with severe AS at low surgical riskbaseline Kansas City Cardiomyopathy Questionnaire (KCCQ), assigned procedure
- Participants
- 943 patients
- Comparison
- Transcatheter aortic valve replacement (TAVR) with a balloon-expandable valve vs surgical aortic valve replacement (SAVR)
- TAVRn = 494
- SAVRn = 449reference
- Primary endpoint
- Health status (KCCQ and Short Form-36 Heath Survey)
- Follow-up
- Baseline, 1 month, 6 months, annually years 1 to 7
Primary result
As reported in the abstract
KCCQ-OS score
- 1 month
- mean treatment difference +16.2 points (95% CI 14.3–18.1)
- 2 years
- mean difference +1.9 points (95% CI 0.2–3.7)
Further findings
Excellent outcome (alive, KCCQ-OS ≥75; no KCCQ-OS decline ≥10 from baseline) · 7 years
- Excellent outcome in both treatment groups
- ∼60%
Original publication
Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis. J Am Coll Cardiol. Published 29 July 2026. doi:10.1016/j.jacc.2026.06.022
Summarised from the published abstract; every number is checked against it