Coronary disease & ACSSecondary analysis
Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA
- Secondary analysis of the ISCHEMIA randomised trial
- risk-adjusted proportional odds models
Authors' conclusion
In ISCHEMIA, both PCI and CABG were associated with better 3-year health status than conservative management. Better angina relief with CABG than PCI was seen at 1, but not 3, years.
Study context
- Population
- Patients with chronic coronary disease in ISCHEMIA
- Participants
- 2,232 / 1,198 / 340
- Comparison
- Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) vs conservative strategy
- Conservativen = 2,232reference
- PCIn = 1,198
- CABGn = 340
- Primary endpoint
- SAQ-7 summary score (SAQ-SS) and angina frequency score (SAQ-AF); higher = better health status
- Follow-up
- 1 and 3 years
Primary result
As reported in the abstract
Change in SAQ-SS · 1 year
CABG vs PCIOdds ratio (95% CI)
SAQ-AF at 1 year
1.54(1.03–2.31)
SAQ-SS at 3 years
1.11(0.78–1.57)
SAQ-AF at 3 years
0.94(0.58–1.54)
Original publication
Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA. Circulation. Published 5 September 2025. doi:10.1161/circulationaha.125.073591
Summarised from the published abstract; every number is checked against it