Health status relationship to ischemia and coronary artery disease severity in the ISCHEMIA trial
Authors' conclusion
Among participants with baseline angina in the ISCHEMIA trial, severe ischemia was independently associated with more frequent angina at baseline and at 1 year, but also with better 1-year overall health status compared with less ischemia. Anatomic CAD severity was not associated with angina severity.
Study context
- Population
- Participants with chronic coronary disease and moderate or severe ischemia by site assessment in the ISCHEMIA trialparticipants with baseline and 1-year Seattle Angina Questionnaire (SAQ) assessments, 2,936 (64.4%) had baseline angina
- Participants
- 4,558 participants
- Comparison
- Severe vs those with less baseline ischemia
- Severe ischemian = 1,587
Methodological detailsproportional odds models, adjusted for age, sex, and baseline health status and stratified by baseline angina
- Proportional odds models, adjusted for age, sex, and baseline health status and stratified by baseline angina
Primary result
As reported in the abstract
Angina frequency at baseline (SAQ AF), participants with baseline angina
Severe ischemia
70.6
SAQ AF
Less ischemia
73.0
SAQ AF
P = 0.029
Further findings
| Outcome | Adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|
| Better overall health status (SAQ Summary Score), participants with baseline angina · 1 year | 1.29 (1.05–1.59) | P = 0.007 | |
| 0.512Adjusted odds ratio (log scale) |
1-year health status by coronary artery disease (CAD) severity, and in asymptomatic patients by ischemia or CAD severity
- No differences
Original publication
Health status relationship to ischemia and coronary artery disease severity in the ISCHEMIA trial. Am Heart J. Published 25 August 2026. doi:10.
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