Heart failure & cardiomyopathies
Heart Failure Among 173,000 Community-Dwelling Participants From 25 Low-, Middle-, and High-Income Countries in the PURE Study
Authors' conclusion
HF incidence and associated mortality vary substantially across countries at different levels of economic development and by geographic region. Hypertension is the largest population-level risk factor for HF globally.
Study context
- Population
- Community-dwelling individuals from 25 high-income countries (HICs), upper middle-income countries (UMICs), lower middle-income countries (LMICs) and low-income countries (LICs) (PURE study)
- Participants
- 172,653 individuals25 countries
- Exposure
- Heart failure (HF) incidence and case fatality by country income group and geographic region
- Outcome
- Age- and sex-standardized HF incidence
- Follow-up
- Median 15 years
Methodological detailsmultinational, 8 geographic regions, median follow-up 15 years
- Multinational
- 8 geographic regions
- Median follow-up 15 years
Main finding
As reported in the abstract
Standardized incident HF rate
- Overall standardized HF incidence per 1,000 person-years
- 0.39 (95% CI 0.36-0.41)
- Sub-Saharan Africa
- 1.18 (95% CI 0.95- 1.41)
- Europe and Central Asia
- 0.86 (95% CI 0.72-1.00)
- South Asia, lowest
- 0.19 (95% CI 0.15-0.22)
Observational data: associations, not effects.
Further findings
| Outcome | HICs | LICs |
|---|---|---|
| 30-day case fatality · highest in LICs, lowest in HICs | 11% | 59% |
| 5-year case fatality after HF diagnosis · highest in LICs, lowest in HICs | 28% | 77% |
- 30-day case fatality — South Asia
- 63%
- 30-day case fatality — Sub-Saharan Africa
- 63%
- 30-day case fatality — North America, lowest
- 12%
- 5-year case fatality after HF diagnosis — South Asia
- 81%
- 5-year case fatality after HF diagnosis — Sub-Saharan Africa
- 75%
- 5-year case fatality after HF diagnosis — North America, lowest
- 25%
PAF for incident HF from 13 modifiable risk factors
- PAF attributable to the 13 modifiable risk factors
- >71%
- Hypertension, largest PAF
- 25%
Original publication
Heart Failure Among 173,000 Community-Dwelling Participants From 25 Low-, Middle-, and High-Income Countries in the PURE Study. J Am Coll Cardiol. Published 22 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →