Heart failure & cardiomyopathies
Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in Heart Failure with Preserved Ejection Fraction (HFpEF) and HFmrEF: Insights From REDUCE LAP-HF II
Authors' conclusion
Longer duration of HFpEF diagnosis is associated with more advanced cardiac remodeling and dysfunction and higher risk of worsening HF
Study context
- Population
- Patients with heart failure (HF), LVEF ≥40% and exercise pulmonary capillary wedge pressure ≥25 mm Hg
- Participants
- 626 patients
- Comparison
- HF duration >3 years vs 1-3 years vs <1 year
Primary result
As reported in the abstract
Cardiac structure/function and hemodynamics by HF duration
Biatrial myopathy
Resting PCWP elevation
| Outcome | >3 years | 1-3 years | <1 year |
|---|---|---|---|
| LV global longitudinal strain, median (Q1-Q3) | 16.4% [Q1-Q3: 14.3%-18.6%] | 17.7% [Q1-Q3: 15.4%-20.0%] | 18.4% [Q1-Q3: 16.3%-20.5%] |
| RV free wall strain, median (Q1-Q3) | 20.8% [Q1-Q3: 16.7%-24.6%] | 22.2% [Q1-Q3: 17.6%-26.1%] | 24.4% [Q1-Q3: 19.2%-27.2%] |
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HF event risk | 1.70 (1.17–2.48) | P = 0.006 | |
| 0.512Hazard ratio (log scale) |
Atrial shunt response across duration groups
- No significant heterogeneity in atrial shunt response across duration groups
Original publication
Heart Failure Duration, Cardiac Remodeling, Dysfunction, and Hemodynamic Severity in HFpEF and HFmrEF: Insights From REDUCE LAP-HF II. JACC Heart Fail. Published 5 June 2026. doi:10.
Summarised from the published abstract; every number is checked against it