Heart failure & cardiomyopathiesCohort study
Heart Failure Patients with Improved Ejection Fraction: Insights from the Metabolic Exercise Cardiac Kidney Indexes (MECKI) Score Database
- Retrospective cohort study
Authors' conclusion
Heart failure with improved ejection fraction represents a peculiar group of HF patients whose clinical, laboratory, electrocardiographic, echocardiographic, and exercise characteristics parallel the recovery of systolic function. Nonetheless, these patients remain at risk for adverse outcome.
Study context
- Population
- Heart failure (HF) patients in the MECKI score database
- Participants
- 7,948 patients
- Exposure
- HFimpEF vs pHFrEF
- HFimpEFn = 1,504
- pHFrEFn = 6,017reference
- Outcome
- Composite of:
- CV death
- LV assist device implantation
- Urgent heart transplantation
- Follow-up
- Median 1490 days
Main finding
As reported in the abstract
CV mortality
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HFimpEF | pHFrEF |
|---|---|---|
| Clinical, laboratory and exercise characteristics | ||
| LVEF | 44.0 [41.0-47.0]% | 29.7 [24.1-34.5]% |
| BNP | 122 [65-296] pg/ml | 373 [152-888] pg/ml |
| Haemoglobin | 13.5 [12.2-14.6] g/dl | 13.7 [12.5-14.7] g/dl |
| MDRD renal function | 72.0 [56.7-89.3] ml/min | 70.4 [54.5-85.3] ml/min |
| Peak oxygen uptake | 62.2 [50.7-74.1]% predicted | 52.6 [41.8-64.3]% predicted |
| VE/VCO2 slope | 30.0 [26.9-34.4] | 32.1 [28.0-38.0] |
- Clinical, laboratory and exercise characteristics: p < 0.001 for all
Original publication
Heart Failure Patients with Improved Ejection Fraction: Insights from the MECKI Score Database. Eur J Heart Fail. Published 3 October 2023. doi:10.1002/ejhf.3031
Summarised from the published abstract; every number is checked against it