Heart failure & cardiomyopathiesCohort study
Heart Failure With Improved Ejection Fraction in ACHD With Biventricular Physiology and Systemic Left Ventricle
- Retrospective study
Authors' conclusion
These data support the use and optimization of GDMT in this subgroup of CHD patients, and the need for ongoing clinical and imaging surveillance.
Study context
- Population
- Adults with congenital heart disease (CHD), biventricular physiology, and systemic left ventricular (LV) presenting with HFrEF (2003–2023)
- Participants
- 327 adults
- Exposure
- HF with improved EF (HFimpEF) compared to patients without improvement in LVEF
- HFimpEFn = 63
Main finding
As reported in the abstract
Prevalence of HFimpEF
Patients with HFimpEF
63 (19%)
Observational data: associations, not effects.
Further findings
Correlates of HFimpEF
- Guideline-directed medical therapy (GDMT) use (higher baseline and ΔGDMT) was associated with great odds of HFimpEF
All-cause mortality and cardiovascular events
- HFimpEF vs patients without improvement in LVEF: decrease in all-cause mortality
- 26%
- HFimpEF vs patients without improvement in LVEF: decrease in cardiovascular events
- 28%
- multivariable analysis
HFrEF relapse among the 63 patients with HFimpEF
- Of the 63 patients with HFimpEF, HFrEF relapse
- 27%
- HFrEF relapse was associated with higher risk of cardiovascular events
Original publication
Heart Failure With Improved Ejection Fraction in ACHD With Biventricular Physiology and Systemic Left Ventricle. JACC Adv. Published 21 July 2026. doi:10.1016/j.jacadv.2026.103042
Summarised from the published abstract; every number is checked against it