Heart failure & cardiomyopathiesMechanistic study
Heart-Lung Interactions in heart failure with preserved ejection fraction (HFpEF)
- Mechanistic study
Authors' conclusion
Patients with HFpEF that dynamically hyperinflate during exercise have greater PCWP as measured with reference to atmospheric pressure. The severity of hyperinflation scaled proportionally to higher exercise PCWP.
Study context
- Population
- Patients with HFpEF (71 ± 7 years, 70% female) studied at rest, 20-W and peak exercise with right heart catheterization
- Participants
- 55 patients
- Comparison
- Dynamic hyperinflation (DH) vs typical during exercise
- Outcome
- Association of DH and expiratory flow limitation (EFL) with PCWP during exercise
- Follow-up
- 20-W and peak exercise
Main finding
As reported in the abstract
PCWP
| Group | Value | Pulmonary capillary wedge pressure (PCWP) at peak exercise |
|---|---|---|
| DH | 24 ± 6 mm Hg | 44 ± 9 mm Hg |
| Typical | 18 ± 6 mm Hg | 31 ± 6 mm Hg |
- DH vs Typical: P = 0.033 — 20-W exercise
- DH vs Typical: P = 0.002 — peak exercise
- Degree of dynamic inflation vs PCWP at 20-W, r2 = 0.196
- P = 0.001
- Degree of dynamic inflation vs PCWP at peak, r2 = 0.204
- P < 0.001
- Degree of dynamic inflation vs mPAP at 20-W and peak
- P < 0.001
Original publication
Heart-Lung Interactions in HFpEF. JACC Heart Fail. Published 26 June 2025. doi:10.1016/j.jchf.2025.102523
Summarised from the published abstract; every number is checked against it