Cardio-oncology & otherCohort study
Heart Transplant and Pregnancy
- Retrospective cohort study
- registry-based
Authors' conclusion
There was no difference in graft loss from delivery in HTRs who developed preeclampsia during pregnancy. Regardless of preeclampsia, pregnant HTRs are more likely than the general population to experience severe maternal morbidity.
Study context
- Population
- Adult heart transplant recipients with pregnancy outcomes ≥20 weeks' gestation, Transplant Pregnancy Registry International, 1986–2022
- Participants
- 146 pregnancies
- Exposure
- Preeclampsia vs no preeclampsia
- Preeclampsian = 42
- Outcome
- Graft loss
- Follow-up
- Within 2 years from delivery
Main finding
Graft loss at 2 years · 2 years
Adjusted hazard ratio
0.79
95% CI 0.37–1.69
P = 0.54
By group
Preeclampsia vs No preeclampsia
adjusted HR 0.79 (95% CI 0.37–1.69); P = 0.54
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Gestational age at birth
P < 0.01
Birth weight
P < 0.01
Safety
Severe maternal morbidity
Original publication
Heart Transplant and Pregnancy. JACC Heart Fail. doi:10.1016/j.jchf.2024.11.016
Summarised from the published abstract; every number is checked against it