Coronary disease & ACSRandomised controlled trial
Helicobacter pylori Screening After Acute Myocardial Infarction
- Cluster randomised crossover trial
- nationwide
- open-label
- 2-period, 2-sequence
- registry-based
- 35 Swedish hospitals in 18 clusters
Authors' conclusion
Among unselected patients with acute myocardial infarction, routine H pylori screening did not significantly reduce the risk of upper gastrointestinal bleeding.
Study context
- Population
- Patients hospitalized for acute MI, Sweden, 2021–2024
- Participants
- 18,466 patients
- Comparison
- Routine H pylori screening vs usual care
- Screeningn = 9,245
- Usual caren = 9,221reference
- Primary endpoint
- Upper gastrointestinal bleeding
- Follow-up
- Median 1.9 years
Primary result
As reported in the abstract
Relative risk
0.90
95% CI 0.77–1.05
P = 0.18
Events by treatment group
Screening
299
events
Usual care
336
events
Screening vs Usual care
RR 0.90 (95% CI 0.77–1.05); P = 0.18
Further findings
Upper GI bleeding, by anemia (predefined subgroups)
- No anemia
- RR, 0.98; 95% CI, 0.80-1.21
- Mild anemia
- RR, 0.64; 95% CI, 0.42-0.98
- Moderate to severe anemia
- RR, 0.44; 95% CI, 0.23-0.87
- P for interaction = .03
- nonmultiplicity adjusted
- heterogeneous intervention effect
Original publication
Helicobacter pylori Screening After Acute Myocardial Infarction. JAMA. Published 7 October 2025. doi:10.1001/jama.2025.15047
Summarised from the published abstract; every number is checked against it