Valvular & structural heart diseaseCohort study
Hemodynamic and Metabolic-Inflammatory Phenotyping Across the Cardiac Index Spectrum in Moderate and Severe Tricuspid Regurgitation: Prognostic Implications
- prospective study
Authors' conclusion
In moderate and severe TRs, CI profiling captures cardiac and extracardiac determinants of flow and independently predicts outcomes beyond conventional TR grading and staging. Both low and high CIs identify high-risk patients, while an intermediate CI indicates a balanced, prognostically favorable state. CI profiling may refine risk stratification, guide individualized treatment strategies, and optimize patient selection and timing for tricuspid valve interventions.
Study context
- Population
- Outpatients with atrial secondary, nonatrial secondary, and lead-associated moderate and severe tricuspid regurgitation (TRs) without ≥moderate left-sided valve diseaseoutpatients enrolled
- Participants
- 300 outpatients
- Exposure
- Patients were stratified by CI tertiles
- Outcome
- all-cause mortality or heart failure hospitalization
Main finding
As reported in the abstract
This pattern persisted across TR severity, cause, staging systems, and adiposity categories
P <0.05 for all
Observational data: associations, not effects.
Further findings
CI and TR severity
- CI decreased with TR severity but showed wide interindividual variability
Hypodynamic-uncoupled profile (low CI)
- more advanced right ventricle-pulmonary arterial uncoupling and biatrial dysfunction versus the other tertiles
- P < 0.05
Hyperdynamic-congestive phenotype (high CI)
- advanced congestion, reduced systemic vascular resistance, and heightened systemic inflammation, metabolic-nutritional derangements, and mitochondrial dysfunction versus the other tertiles
- P < 0.05
Intermediate CI profile
- Intermediate CI showed the most favorable hemodynamic and laboratory profile
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it