Heart failure & cardiomyopathies
Hemodynamic-Guided Heart Failure Management in Patients With Either Prior Heart Failure (HF) Hospitalization or Elevated Natriuretic Peptides
Authors' conclusion
Consistent effects of hemodynamic-guided HF management across enrollment strata in GUIDE-HF support consideration of hemodynamic monitoring in the expanded group of patients with chronic HF and elevated NPs without recent HFH.
Study context
- Population
- Patients with New York Heart Association (NYHA) class II–IV HF and either previous heart failure hospitalization (HFH) or elevated NP levels999 evaluable
- Participants
- 1,000 patients
- Comparison
- Hemodynamic-guided HF management vs usual care
Methodological detailssubgroup analysis by enrollment stratum
- Subgroup analysis by enrollment stratum
Primary result
As reported in the abstract
Effect of hemodynamic monitoring on primary endpoint by enrollment stratum (HFH n = 557 vs elevated natriuretic peptides (NPs) n = 442)
- Effects consistent across enrollment strata, full study duration (interaction P)
- P = 0.71
- Effects consistent across enrollment strata, pre-COVID-19 analysis (interaction P)
- P = 0.58
Further findings
Event rates by enrollment stratum (NP vs HFH)
- Event rates lower in NP group, full follow-up (NP vs HFH)
- 40.9 per 100 patient-years vs 82.0 per 100 patient-years
- Event rates lower in NP group, pre-COVID-19 analysis (NP vs HFH)
- 43.6 per 100 patient-years vs 88.0 per 100 patient-years
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Hemodynamic-Guided Heart Failure Management in Patients With Either Prior HF Hospitalization or Elevated Natriuretic Peptides. JACC Heart Fail. Published 12 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →