Pulmonary vascular disease & thromboembolism
Hemodynamic Super-Response to Mechanical Thrombectomy in Patients With Intermediate-Risk Pulmonary Embolism
Authors' conclusion
Patients with intermediate-risk pulmonary embolism with the more severe hemodynamic derangements had the greatest improvement in CI post thrombectomy. This group can be identified with commonly available noninvasive indices of right ventricular dysfunction.
Study context
- Population
- Intermediate-risk PE undergoing mechanical thrombectomy with pulmonary artery catheter-derived hemodynamics pre- and postprocedure
- Participants
- 105 complete hemodynamic profiles
- Exposure
- Super-responders vs non-super-responders to mechanical thrombectomy
- Super-respondersn = 41
- Outcome
- Variables associated with hemodynamic super-response (CI increase ≥25% postthrombectomy)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hemodynamic super-response (CI increase ≥25% postthrombectomy)
Odds ratio (95% CI)
Left ventricular outflow tract velocity-time integral ≤15 cmunivariable
16.19(1.97–133.24)
Tricuspid annular plane systolic excursion/pulmonary artery systolic pressure ≤0.34 mm/mm Hgunivariable
6.5(2.13–19.83)
Substantial inferior vena cava contrast refluxunivariable
2.53(1.09–5.88)
Preprocedure CI ≤2.2 L/min per m²multivariable
3.76(1.09–13.0)
Per m², as printed
Observational data: associations, not effects.
Further findings
Baseline CI
| Outcome | Super-responders | Non-super-responders |
|---|---|---|
| Change in CI postthrombectomy | mean change 0.8 ± 0.4 L/min per m² | mean change 0.1 ± 0.4 L/min per m² |
Original publication
Hemodynamic Super-Response to Mechanical Thrombectomy in Patients With Intermediate-Risk Pulmonary Embolism. Circ Cardiovasc Interv. Published 3 September 2025. doi:10.
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