Valvular & structural heart diseaseResearch article
Hepatic Extracellular Volume Fraction by CMR: A Novel Prognostic Marker in Tricuspid Regurgitation
- Consecutive patients with moderate or greater tricuspid regurgitation (TR) who underwent cardiac magnetic resonance with hepatic T1 mapping
- stratified by hepatic ECV tertiles
Authors' conclusion
Hepatic ECV is a novel prognostic marker that provides incremental risk stratification in TR and has potential to impact therapeutic decision-making in the era of expanded treatment options for TR.
Study context
- Population
- Consecutive patients with moderate or greater TR who underwent cardiac magnetic resonance with hepatic T1 mapping
- Participants
- 234 patients
- Comparison
- Hepatic ECV tertiles
- Outcome
- All-cause mortality
- Follow-up
- Mean 2.2 years
Main finding
As reported in the abstract
Hazard ratio
1.62
95% CI 1.06–2.48
P = 0.027
By group
hepatic ECV tertiles
hazard ratio 1.62 (95% CI 1.06–2.48); P = 0.027
- deaths
- 43 (18.4%)
Further findings
Right ventricular ejection fraction
Right ventricular end-diastolic volume index
| Outcome | tertile 1 | tertile 2 | tertile 3 |
|---|---|---|---|
| Severe TR (regurgitant fraction ≥50%) | Not reported in the abstract | Not reported in the abstract | 29.5% |
- Severe TR (regurgitant fraction ≥50%) — tertiles 1 and 2 (mean)
- 10.9%
- Right ventricular ejection fraction: P <0.001
- Right ventricular end-diastolic volume index: P <0.001
- Severe TR (regurgitant fraction ≥50%): P <0.001
Hepatic ECV
- mean hepatic ECV
- 37.7±9.0%
- tertile cutoffs
- 32.5% and 41.3%
Incremental prognostic value (forward stepwise analysis)
- model discrimination χ² improved from 24.4 to
- 30.1
- P =0.02
Original publication
Hepatic Extracellular Volume Fraction by CMR: A Novel Prognostic Marker in Tricuspid Regurgitation. Circ Cardiovasc Imaging. Published 22 January 2026. doi:10.1161/circimaging.125.018988
Summarised from the published abstract; every number is checked against it