Randomised controlled trial
Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs
- Randomised controlled trial
- double-blind
- repeated crossover
- single outpatient research clinic in Sweden
- 1468 completed treatment periods (median length, 56 days)
Authors' conclusion
These data reveal substantial heterogeneity in blood pressure response to drug therapy for hypertension
Study context
- Population
- Men and women with grade 1 hypertension at low risk for CV events270 with completed periods
- Participants
- 280 men
- Comparison
- Lisinopril vs candesartan vs hydrochlorothiazide vs amlodipine
- Primary endpoint
- Ambulatory daytime SBP
- Follow-up
- End of each treatment period
Primary result
As reported in the abstract
Heterogeneity in SBP response between individuals
BP response to different treatments varied considerably between individuals
P < .001
Average additional SBP lowering potentially achievable by personalized treatment
4.4 mm Hg
Original publication
Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs. JAMA. Published 11 April 2023. doi:10.1001/jama.2023.3322
Summarised from the published abstract; every number is checked against it