Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial
Authors' conclusion
These data reveal substantial heterogeneity in blood pressure response to drug therapy for hypertension
Study context
- Population
- Men and women with grade 1 hypertension at low risk for CV events270 with completed periods
- Participants
- 280 men
- Comparison
- Lisinopril vs candesartan vs hydrochlorothiazide vs amlodipine
- Primary endpoint
- Ambulatory daytime SBP
- Follow-up
- End of each treatment period
Methodological detailsdouble-blind, repeated crossover, single outpatient research clinic in Sweden, 1468 completed treatment periods (median length, 56 days)
- Double-blind
- Repeated crossover
- Single outpatient research clinic in Sweden
- 1468 completed treatment periods (median length, 56 days)
Primary result
As reported in the abstract
Heterogeneity in SBP response between individuals
- BP response to different treatments varied considerably between individuals
- P < .001
- Average additional SBP lowering potentially achievable by personalized treatment
- 4.4 mm Hg
Original publication
Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial. JAMA. Published 11 April 2023. doi:10.
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