Prevention & lipidsCohort study
Heterogeneity in Lipoprotein(a) Profile Changes Across the Menopausal Transition
- Prospective cohort study
- UK Biobank
Authors' conclusion
Relying on a single lifetime Lp(a) measurement may miss reclassification across risk-enhancing thresholds during menopause, particularly for women with intermediate premenopausal levels.
Study context
- Population
- UK Biobank women with Lp(a) measured at visits 1 and 2
- Participants
- 4,562 women
- Exposure
- Menopausal transition vs remaining premenopausal or postmenopausal
- Underwent menopausen = 415
- Remained premenopausaln = 532reference
- Remained postmenopausaln = 3,615reference
- Outcome
- Incident Lp(a) ≥125 nmol/L at visit 2 (Poisson regression)
- Follow-up
- Visit 2 (median 4 years)
Main finding
As reported in the abstract
Incident Lp(a) ≥125 nmol/L, women with intermediate visit 1 Lp(a) (75-125 nmol/L) · visit 2
Relative risk
2.27
95% CI 1.36–3.78
Events by group
Underwent menopause vs Remained pre- or postmenopausal
RR 2.27 (95% CI 1.36–3.78)
Observational data: associations, not effects.
Further findings
Median, nmol/L
| Outcome | Underwent menopause | Remained premenopausal | Remained postmenopausal |
|---|---|---|---|
| Visit 1 Lp(a) · mean visit 1 | Not reported in the abstract | 19 | 23 |
Change in Lp(a) between visits
- Intermediate visit 1 Lp(a), underwent menopause: median increase, ≈fourfold greater than remaining pre- or postmenopausal
- 34.9 nmol/L
- Overall median changes modest
Original publication
Heterogeneity in Lipoprotein(a) Profile Changes Across the Menopausal Transition. Eur J Prev Cardiol. Published 17 September 2026. doi:10.1093/eurjpc/zwag496
Summarised from the published abstract; every number is checked against it