Heart failure & cardiomyopathiesCohort study
HFpEF-ABA Score for the Diagnosis and Prognosis of HFpEF in Outpatients With Type 2 Diabetes
- prospective, multicenter DIABET-IC cohort
Authors' conclusion
In ambulatory adults with T2D, the HFpEF-ABA score showed moderate diagnostic discrimination for HFpEF and was associated with adverse clinical outcomes at follow-up.
Study context
- Population
- Outpatients with type 2 diabetes (T2D)outpatients with T2D
- Participants
- 1,125 outpatients
- Exposure
- HFpEF-ABA score against HFpEF diagnosis based on the European Society of Cardiology guidelines criteria and confirmed by a cardiologist
Main finding
As reported in the abstract
HFpEF confirmed
HFpEF confirmed
190 participants (16.9%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Outcomes per 10-percentage-point increase in HFpEF probability · 3 years — Per 10-percentage-point increase in HFpEF probability · all-cause death | 1.34 (1.17–1.54) | |
| Outcomes per 10-percentage-point increase in HFpEF probability · 3 years — Per 10-percentage-point increase in HFpEF probability · HF hospitalization | 1.16 (0.94–1.43) | |
| Outcomes per 10-percentage-point increase in HFpEF probability · 3 years — Per 10-percentage-point increase in HFpEF probability · composite endpoint | 1.28 (1.14–1.44) | |
| 0.512Hazard ratio (log scale) |
Outcomes with scores ≥75% · 3 years
| Comparison | HR (95% CI) | |
|---|---|---|
| Scores ≥75% · death | 2.40 (1.45–3.97) | |
| Scores ≥75% · HF hospitalization | 2.51 (1.10–5.72) | |
| Scores ≥75% · composite | 2.41 (1.55–3.73) | |
| 0.20.5125Hazard ratio (log scale) |
Diagnostic performance of HFpEF-ABA score
- area under the receiver operating characteristic curve
- 0.75 (95% CI: 0.71-0.79)
Events over follow-up · 3 years
- deaths
- 61
- Heart failure (HF) hospitalizations
- 23
Original publication
HFpEF-ABA Score for the Diagnosis and Prognosis of HFpEF in Outpatients With Type 2 Diabetes. JACC Adv. Published 2 September 2026. doi:10.1016/j.jacadv.2026.103196
Summarised from the published abstract; every number is checked against it