Cardio-oncology & otherRandomised controlled trial
Hierarchical Composite Outcomes and Win Ratio Methods in Cardiovascular Trials: A Review and Consequent Guidance
- Methodological review of randomised trials
Authors' conclusion
When used wisely, the win ratio is a valuable tool in the analysis of RCTs.
Study context
- Population
- Cardiovascular randomized clinical trials (RCTs) using the win ratio published January 2022 to July 2024
- Participants
- 36 RCTs
Primary result
As reported in the abstract
Use of the win ratio in cardiovascular RCTs
- Eligible RCTs, mainly in HF and ischemic heart disease
- 36
- Pharmaceutical intervention
- 26
- Procedure intervention
- 7
- Treatment strategy intervention
- 3
- Hierarchical composite combining event outcomes and quantitative measures
- 23
Original publication
Hierarchical Composite Outcomes and Win Ratio Methods in Cardiovascular Trials: A Review and Consequent Guidance. Circulation. Published 2 June 2025. doi:10.1161/circulationaha.124.070251
Summarised from the published abstract; every number is checked against it