Valvular & structural heart disease
High-Gradient Aortic Stenosis With Valve Area >1.0 cm2: The "Forgotten" Discordant Hemodynamic Phenotype
Authors' conclusion
The underlying relative high-flow status is responsible for HG in patients with HG-AVA >1. This profile has better prognosis than others, being related to underlying younger age and better general and cardiac conditions, but aortic valve replacement may still benefit these patients.
Study context
- Population
- Patients with aortic stenosis (AS) classified by hemodynamic phenotype1,523 deaths
- Participants
- 3,209 patients
- Exposure
- High-gradient (HG) AS with AVA >1.0 cm² vs other AS phenotypes
- HG-AVA >1n = 230reference
- Outcome
- All-cause mortality
- Follow-up
- 944 days (Q1-Q3: 27-2,212 days)
Main finding
As reported in the abstract
Each group vs HG-AVA >1Hazard ratio (95% CI)
HG-AVA ≤1
1.4(1.1–1.7)
LG-AVA ≤1
2.8(2.2–3.6)
Moderate AS
1.4(1.1–1.7)
Observational data: associations, not effects.
Further findings
- Characteristics of HG-AVA >1 vs others
- 7.2% · 230
- Survival with vs without aortic valve replacement in HG-AVA >1
- P < 0.001
- Survival with vs without aortic valve replacement in HG-AVA >1: better survival with replacement, after balancing the 2 groups
Characteristics of HG-AVA >1 vs others
- HG-AVA >1 younger, more often male, fewer comorbidities, larger body surface area and stroke volume, more bicuspid valve vs others
Original publication
High-Gradient Aortic Stenosis With Valve Area >1.0 cm2: The "Forgotten" Discordant Hemodynamic Phenotype. JACC Cardiovasc Imaging. Published 18 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →