Coronary disease & ACSRandomised controlled trial
High-intensity interval training combined with moderate-intensity continuous training in post-PCI acute myocardial infarction patients: A randomized controlled trial
- single-center, three-arm parallel, assessor-blinded randomized controlled trial
- 12-week supervised cardiac rehabilitation
Authors' conclusion
Combined HIIT and MICT training produces synergistic effects, superior to single modalities, in improving cardiopulmonary function and cardiac remodeling in post-PCI AMI patients, with comparable safety profile, providing evidence-based optimization strategy for cardiac rehabilitation.
Study context
- Population
- Clinically stable post-PCI acute myocardial infarction (AMI) patientsenrolled and randomized
- Participants
- 204 patients
- Comparison
- combined high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) training compared to single training modalities
- HIIT+MICTn = 68
- MICTn = 68
- HIITn = 68
- Primary endpoint
- Change in VO2peak
Primary result
As reported in the abstract
HIIT+MICT vs MICT: P < 0.001 · HIIT+MICT vs HIIT: P = 0.003
- HIIT+MICT reaching clinically meaningful improvement (≥3 mL/kg/min)
- 76.7%
Secondary outcomes
Left ventricular ejection fraction (LVEF) and NT-proBNP in the combined training group
- LVEF increased
- 8.6 ± 3.2%
- NT-proBNP decreased
- −706 pg/mL
Safety
Major adverse cardiovascular events (MACE)
- Incidence of MACE
- 2.9%
- without significant inter-group differences
- P = 0.85
Original publication
High-intensity interval training combined with moderate-intensity continuous training in post-PCI acute myocardial infarction patients: A randomized controlled trial. Am Heart J. Published 8 May 2026. doi:10.1016/j.ahj.2026.107472
Summarised from the published abstract; every number is checked against it