Coronary disease & ACSResearch article
High-Output Mechanical Circulatory Support in Left Main Interventions
- First-in-human study
Authors' conclusion
In this first-in-human study, use of the Magenta Elevate low-profile, high-output catheter during HR-PCI was safe and provided substantial cardiac support. During prolonged interventional LM occlusions, the system unloaded the LV, maintaining a normal MAP and dΔPAoLV.
Study context
- Population
- Patients undergoing high-risk percutaneous coronary intervention (HR-PCI), including prolonged unprotected left main balloon occlusions8 with LM occlusions
- Participants
- 14 patients
- Outcome
- Major device-related adverse events (primary safety endpoint)
Main finding
As reported in the abstract
- No major device-related adverse events
Further findings
| Outcome | change (mm Hg) (CI) | P value | |
|---|---|---|---|
| Haemodynamic change during prolonged LM occlusions (20 occlusions) — During occlusion vs Before occlusion · systolic aortic pressure | −35 (−46 to −23) | P < 0.0001 | |
| Haemodynamic change during prolonged LM occlusions (20 occlusions) — During occlusion vs Before occlusion · diastolic pressure | 7 (4–10) | P < 0.0055 | |
| Haemodynamic change during prolonged LM occlusions (20 occlusions) — During occlusion vs Before occlusion · MAP; remained in normal range | −7 (−13 to −2) | P < 0.001 | |
| Haemodynamic change during prolonged LM occlusions (20 occlusions) — During occlusion vs Before occlusion · dΔPAoLV; remained in normal range | −2 (−5 to 4) | P = 0.51 | |
| −60−40−20020Difference, mm Hg (linear scale) |
- Haemodynamic change during prolonged LM occlusions (20 occlusions) — Ventriculo-arterial uncoupling
- 13 of 20 LM balloon occlusions
Mortality · 30 days
- No mortality at 30 days
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
High-Output Mechanical Circulatory Support in Left Main Interventions. JACC Cardiovasc Interv. Published 23 December 2024. doi:10.1016/j.jcin.2024.09.017
Summarised from the published abstract; every number is checked against it