Prevention & lipidsCohort study
High remnant cholesterol and atherosclerotic cardiovascular disease in healthy women and men aged 70–100
- Prospective cohort study
Authors' conclusion
Higher remnant cholesterol was associated with higher incidence of ASCVD in those aged 70-100.
Study context
- Population
- Healthy women and men without atherosclerotic cardiovascular disease (ASCVD), diabetes or lipid-lowering therapy, Copenhagen General Population Study, 2003–15; focus on age 70–100aged 20–100
- Participants
- 90,875 women
- Exposure
- Higher vs lower remnant cholesterol
- Outcome
- Incident ASCVD
- Follow-up
- Median 12.8 years
Main finding
ASCVD in individuals aged 70-100
Hazard ratio
1.31
95% CI 1.20–1.44
Remnant cholesterol per 1.0 mmol/L (39 mg/dL) higher
HR 1.31 (95% CI 1.20–1.44)
Per 1.0 mmol/L, as printed
As reported in the abstract
- Incidence rate of ASCVD, aged 70-100 with remnant cholesterol >1.0 mmol/L (>39 mg/dL) (highest observed)
- 23 per 1000 person-years (95% CI: 21-25)
Observational data: associations, not effects.
Further findings
ASCVD incidence rates per 1.0 mmol/L higher remnant cholesterol, by age
- Highest in individuals aged 70-100
ASCVD by sex
- Similar relationships in women and men separately
Incident ASCVD, whole cohort · median follow-up 12.8 years
- Diagnosed with ASCVD
- 7352
Original publication
High remnant cholesterol and atherosclerotic cardiovascular disease in healthy women and men aged 70–100. Eur J Prev Cardiol. Published 21 February 2025. doi:10.1093/eurjpc/zwaf092
Summarised from the published abstract; every number is checked against it