High-risk coronary atherosclerosis at coronary computed tomography angiography in patients with Family histoRy of coronary Artery disease: an InTERnational multicentre study (The FRATER Study)
Authors' conclusion
This prospective multicenter study shows that patients with a family history of CAD have a higher prevalence of high-risk atherosclerosis.
Study context
- Population
- Consecutive patients undergoing clinically indicated coronary computed tomography angiography (CCTA) for suspected CAD2:1 matched
- Participants
- 480 patients
- Exposure
- Family history (FH) of CAD vs no FH of CAD
- FH of CADn = 160
- No FH of CADn = 320reference
- Outcome
- Prevalence of high-risk atherosclerosis at CCTA
Methodological detailsmatched 2:1, core lab CCTA evaluation
- Matched 2:1
- Core lab CCTA evaluation
Main finding
As reported in the abstract
High-risk atherosclerosis at CCTA
P = 0.0001
Observational data: associations, not effects.
Further findings
High-risk atherosclerosis or obstructive CAD at CCTA (very low probability of obstructive CAD subgroup)
P = 0.0009
Original publication
High-risk coronary atherosclerosis at coronary computed tomography angiography in patients with Family histoRy of coronary Artery disease: an InTERnational multicentre study (The FRATER Study). Eur J Prev Cardiol. Published 23 February 2026. doi:10.
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