Prevention & lipidsCohort study
High-sensitivity C-reactive protein and cardiovascular events in a multi-ethnic cohort: the HEalthy Life In an Urban Setting (HELIUS) study
- Prospective cohort study
- general population
- multi-ethnic
Authors' conclusion
hsCRP was associated with incident cardiovascular events in individuals of European and African descent but not in South Asian individuals, despite higher hsCRP values.
Study context
- Population
- General population, multi-ethnic HELIUS cohort (Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan origin); mean age 44±13 years, 55% female568 CV events
- Participants
- 14,663 participants
- Exposure
- High-sensitivity C-reactive protein (hsCRP) and CV events across ethnic groups
- Outcome
- CV events (from nationwide registries) by hsCRP
- Follow-up
- Median 8.8 (7.8-9.7) years
Main finding
As reported in the abstract
CV events per 1 mg/L increase in hsCRP
Adjusted HR per 1 mg/L hsCRP (95% CI)
European
1.08(1.00–1.16)
African
1.09(1.03–1.16)
Per 1 mg/L increase in hsCRP, as printed
Observational data: associations, not effects.
Further findings
Baseline hsCRP
- Baseline hsCRP — Difference across groups
- p <0.001
Original publication
High-sensitivity C-reactive protein and cardiovascular events in a multi-ethnic cohort: the HELIUS study. Eur J Prev Cardiol. Published 19 November 2025. doi:10.1093/eurjpc/zwaf740
Summarised from the published abstract; every number is checked against it