Coronary disease & ACSCohort study
High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease
- Prospective cohort study
- consecutive patients
- clinicians blinded to troponin results
Authors' conclusion
In patients with chronic coronary artery disease, cardiac troponin predicts risk of myocardial infarction or cardiovascular death independent of cardiovascular risk factors and disease severity.
Study context
- Population
- Consecutive patients with symptoms suggestive of stable angina attending for outpatient coronary angiography; high-sensitivity cardiac troponin I measured before angiographyCAD in 3,888 (92%)
- Participants
- 4,240 patients
- Exposure
- Primary outcome event vs no event
- Eventn = 255
- Outcome
- Myocardial infarction or cardiovascular death
- Follow-up
- During
Main finding
MI or CV death · median follow-up 2.4 years (IQR: 1.3-3.6 years)
Adjusted hazard ratio
2.3
95% CI 1.7–3.0
P < 0.001
By group
Log10 troponin vs No event
adjusted HR 2.3 (95% CI 1.7–3.0); P < 0.001
As reported in the abstract
- Primary outcome events in patients with CAD
- 255 (6%)
- Troponin concentrations 2-fold higher with an event than without
- P < 0.001
Observational data: associations, not effects.
Original publication
High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease. J Am Coll Cardiol. Published 8 August 2023. doi:10.1016/j.jacc.2023.05.046
Summarised from the published abstract; every number is checked against it