Heart failure & cardiomyopathiesCohort study
High-sensitivity cardiac troponin I for enhanced risk stratification in primary prevention for sudden cardiac death in hypertrophic cardiomyopathy
- cohort study
- consecutively enrolled
Authors' conclusion
The hs-cTnI could be an independent predictor of SCD risk for patients with HCM. Integrating hs-cTnI into SCD risk assessment may provide additional indication of ICD implantation for primary prevention.
Study context
- Population
- Patients with confirmed diagnosis of hypertrophic cardiomyopathy (HCM)final analysis, 705 enrolled
- Participants
- 559 patients
- Exposure
- High-sensitivity cardiac troponin I (hs-cTnI) added to the conventional risk score model vs the conventional risk score model
- Outcome
- SCD or SCD-equivalent events including witnessed arrhythmic cardiac arrest and sustained ventricular tachycardia or ventricular fibrillation requiring intervention
- Follow-up
- Mean 862 days
Main finding
As reported in the abstract
Patients experiencing SCD events
51 patients (9.1%)
Observational data: associations, not effects.
Further findings
hs-cTnI and SCD risk
- Significant nonlinear association; independent predictor, adjusted hazard ratio
- 2.93 [95% confidence interval 1.89-4.54], P < .0001
Optimal hs-cTnI threshold for increased risk of SCD
- Optimal threshold
- 0.0405 ng/mL
Predictive performance with addition of hs-cTnI to conventional risk score model
- C-statistic increased from
- 0.752 to 0.813; P = .007
Prognosis with both elevated risk score and hs-cTnI
- Worst prognosis
- P < 0.0001
Baseline characteristics
- Median age
- 53.0 years
- Male
- 66.2%
- With implantable cardioverter-defibrillator (ICD)
- 16.1%
- Median hs-cTnI level
- 0.021 ng/mL
Original publication
High-sensitivity cardiac troponin I for enhanced risk stratification in primary prevention for sudden cardiac death in hypertrophic cardiomyopathy. Heart Rhythm. Published 14 May 2026. doi:10.1016/j.hrthm.2026.05.010
Summarised from the published abstract; every number is checked against it