Coronary disease & ACSCohort study

High-sensitivity HEART Pathway one-and-done troponin strategy is safe and effective

Am Heart JPublished

  • multisite emergency department cohort

Authors' conclusion

Thus, the one-and-done strategy was safe and effective.

Study context

Population
Emergency department patients with acute chest painpatients with acute chest pain
Participants
12,190 patients

Main finding

As reported in the abstract

Eligible for the one-and-done strategy

Eligible (of 12,190)

13.4% (1,628/12,190)

Observational data: associations, not effects.

Further findings

OutcomeValues
Discharged from the emergency department, of those eligibleone-and-done 89.6%
All-cause mortality or myocardial infarction, of those eligible · 30 daysone-and-done 0.2%

Original publication

High-sensitivity HEART Pathway one-and-done troponin strategy is safe and effective. Am Heart J. Published 26 August 2026. doi:10.1016/j.ahj.2026.107588

Summarised from the published abstract; every number is checked against it