High-sensitivity troponins and mortality in the general population
Authors' conclusion
This study demonstrates only modest correlations between hs-troponin T and three hs-troponin I assays and that hs-troponin I assays can provide distinct risk information for mortality in the general population.
Study context
- Population
- Adults without CVD in the 1999–2004 National Health and Nutrition Examination Survey2,188 deaths (488 CV)
- Participants
- 9,810 adults
- Exposure
- Four hs-troponin assays and mortality
- Outcome
- All-cause and CV mortality (per 1 SD log-transformed hs-troponin)
Methodological detailsNHANES 1999-2004
- NHANES 1999-2004
Main finding
As reported in the abstract
All-cause mortality, per 1 SD (log-transformed)
Hazard ratio (95% CI)
Abbott hs-troponin I
1.20(1.13–1.28)
Siemens hs-troponin I
1.10(1.02–1.18)
Ortho hs-troponin I
1.23(1.14–1.33)
Roche hs-troponin T
1.31(1.21–1.42)
Per 1 SD, as printed
Observational data: associations, not effects.
Further findings
Mutually adjusted associations
| HR (95% CI) | ||
|---|---|---|
| Abbott hs-troponin ICV mortality, adjusted for Siemens assay | 1.46 (1.19–1.79) | |
| Abbott hs-troponin ICV mortality, adjusted for Ortho assay | 1.29 (1.09–1.53) | |
| 0.512Hazard ratio (log scale) |
Correlation between assays
- Pearson's correlation coefficients
- 0.53 to 0.77
CV mortality, per 1 SD
- Each assay independently associated, HR per 1 SD
- 1.44 to 1.65
Mutually adjusted associations
- Hs-troponin T associations with all-cause and CV mortality remained significant after adjusting for hs-troponin I
Original publication
High-sensitivity troponins and mortality in the general population. Eur Heart J. Published 2 June 2023. doi:10.
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