Heart failure & cardiomyopathiesMeta-analysis
High Variability in Assays of Blood Markers of Collagen Turnover in Cardiovascular Disease: Implications for Research and Clinical Practice
- Systematic review
- PRISMA
Authors' conclusion
Our findings show that it is challenging to ascertain normal ranges or compare studies for the measurement of fibrosis biomarkers.
Study context
- Population
- Human in-vivo studies of blood markers of collagen turnover (fibrosis) in CVD89 studies
- Participants
- 42 / 32 / 29 / 17
- Comparison
- PIIINP vs PICP vs CITP vs PINP
- PIIINPn = 42
- PICPn = 32
- CITPn = 29
- PINPn = 17
Pooled result
As reported in the abstract
Range of reported values
- Extreme variations in values across studies, especially with different assays, but also with the same assays
Original publication
High Variability in Assays of Blood Markers of Collagen Turnover in Cardiovascular Disease: Implications for Research and Clinical Practice. Eur J Heart Fail. Published 9 July 2024. doi:10.1002/ejhf.3375
Summarised from the published abstract; every number is checked against it