Arrhythmias & electrophysiologyResearch article
High-Voltage Pulsed Field Ablation
- single-center series
- consecutive patients
Authors' conclusion
Preliminary findings from this prospective series show efficacy of hv-PFA in NICM patients with prior multiple unsuccessful VT ablations. Further studies are required to define the safety profile of this novel ablation system.
Study context
- Population
- Nonischemic cardiomyopathy (NICM) patients undergoing repeat ablation of recurrent monomorphic ventricular tachycardia (VT) with an 8.5-F force-sensing high-voltage pulsed field ablation (hv-PFA) catheter between July 2024 and August 2025consecutive patients, 9 procedures in total, as 1 patient underwent 3 ablations for VT recurrence
- Participants
- Seven patients
Main finding
As reported in the abstract
Procedural success (noninducibility of any VT and absence of residual abnormal electrograms within bipolar voltage area <1.5 mV)
- Procedural success was achieved in all patients
Further findings
Arrhythmic recurrence · median follow-up of 10 months (320 days [Q1-Q3: 183-407 days])
- Recurrence after procedures
- 3 (33.3%) of 9 procedures
- Patients with recurrence
- 2 (28.6%) of 7 patients
Baseline and procedural characteristics
- Mean age
- 58 ± 10.4 years
- Female
- 1 female [14.3%]
- Mean number of prior procedures
- 2.29 ± 1.11
- Lesions per procedure
- median 14 lesions [Q1-Q3: 9-17 lesions]
Safety
Electromagnetic interference
- Defibrillator malfunction, requiring generator replacement
- 2 (22.2%) procedures
- Mapping system malfunction
- 3 (33.3%) procedures
Original publication
High-Voltage Pulsed Field Ablation. JACC Clin Electrophysiol. Published 22 May 2026. doi:10.1016/j.jacep.2026.04.016
Summarised from the published abstract; every number is checked against it